Article

The psychosis risk factor <i>RBM12</i> encodes a novel repressor of GPCR/cAMP signal transduction

2023-01-12

Abstract excerpt

RBM12 is a high-penetrance risk factor for familial schizophrenia and psychosis, yet its precise cellular functions and the pathways to which it belongs are not known. We utilize two complementary models, HEK293 cells and human iPSC-derived neurons, and delineate RBM12 as a novel repressor of the G protein-coupled receptor/cyclic AMP/protein kinase A (GPCR/cAMP/PKA) signaling axis. We establish that loss of RBM12...

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Literature Corpus work: 767611f2-1e80-50d7-b0a6-12b6f9d7edcc
DOI: 10.1101/2023.01.12.523776

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