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Dysfunction of cAMP-PKA-calcium signaling axis in striatal medium spiny neurons: a role in schizophrenia and Huntington’s disease pathogenesis

2021-10-08

Abstract excerpt

<h4>Summary</h4> <h4>Background</h4> Striatal medium spiny neurons (MSNs) are preferentially lost in Huntington’s disease. Genomic studies also implicate a direct role for MSNs in schizophrenia, a psychiatric disorder known to involve cortical neuron dysfunction. It remains unknown whether the two diseases share similar MSN pathogenesis or if neuronal deficits can be attributed to cell type-dependent biological...

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Literature Corpus work
dba084cb-46fc-5284-90f1-9fe883d4a9e3
DOI
10.1101/2021.10.08.463614
Open publication

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Dysfunction of cAMP-PKA-calcium signaling axis in striatal medium spiny neurons: a role in schizophrenia and Huntington’s disease pathogenesisDOI 10.1101/2021.10.08.463614
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