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Article

Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis.

Disease models & mechanisms - 1 May 2013

Estes Patricia S, Daniel Scott G, McCallum Abigail P, Boehringer Ashley V, Sukhina Alona S, Zwick Rebecca A, Zarnescu Daniela C

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by complex neuronal and glial phenotypes. Recently, RNA-based mechanisms have been linked to ALS via RNA-binding proteins such as TDP-43, which has been studied in vivo using models ranging from yeast to rodents. We have developed a Drosophila model of ALS based on TDP-43 that recapitulates several aspects of pathology, including motor neuron...

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Identifiers

PMID: 23471911
DOI: 10.1242/dmm.010710
PMCID: PMC3634655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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