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Analysis of pre-symptomatic <i>Drosophila</i> models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degeneration

2022-06-20

Abstract excerpt

Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) share phenotypic and molecular commonalities, including the fact that they can be caused by mutations in ubiquitous proteins involved in RNA metabolism, namely SMN, TDP-43 and FUS. Although this suggests the existence of common disease mechanisms, there is currently no model to explain the resulting motor neuron dysfunction. In this work we gene...

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Literature Corpus work
2356080b-7a68-5a3d-940d-9cdd228fe223
DOI
10.1101/2022.06.20.496821
Open publication

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Analysis of pre-symptomatic <i>Drosophila</i> models for ALS and SMA reveals convergent impact on functional protein complexes linked to neuro-muscular degenerationDOI 10.1101/2022.06.20.496821
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