Article

An <i>in vitro</i> neurogenetics platform for precision disease modeling in the mouse

2022-01-21

Abstract excerpt

The power and scope of disease modeling can be markedly enhanced through the incorporation of broad genetic diversity. In the the mouse, the introduction of pathogenic mutations into a single inbred strain sometimes fails to mimic human disease. We describe a cross-species precision disease modeling platform that exploits mouse genetic diversity to bridge cell-based modeling with whole organism analysis. We develo...

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Literature Corpus work: 52567c2d-f13c-5461-92ff-1e4f27409ec6
DOI: 10.1101/2022.01.21.477242

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