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Article

An in vitro neurogenetics platform for precision disease modeling in the mouse.

Science advances - 5 Apr 2024

Cortes Daniel E, Escudero Mélanie, Korgan Austin C, Mitra Arojit, Edwards Alyssa, Aydin Selcan C, Munger Steven C, Charland Kevin, Zhang Zhong-Wei, O'Connell Kristen M S, Reinholdt Laura G, Pera Martin F

Abstract excerpt

The power and scope of disease modeling can be markedly enhanced through the incorporation of broad genetic diversity. The introduction of pathogenic mutations into a single inbred mouse strain sometimes fails to mimic human disease. We describe a cross-species precision disease modeling platform that exploits mouse genetic diversity to bridge cell-based modeling with whole organism analysis. We developed a...

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PMID: 38569042
DOI: 10.1126/sciadv.adj9305
PMCID: PMC10990289

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