Article
Mouse population genetics phenocopies heterogeneity of human <i>Chd8</i> haploinsufficiency
2022-08-26
Abstract excerpt
Preclinical models of neurodevelopmental disorders typically use single inbred strains which fail to capture human genetic and symptom heterogeneity that is common clinically. We tested if systematically modeling human genetic diversity in mouse genetic reference panels would recapitulate population and individual differences in responses to a syndromic mutation in the high-confidence autism risk gene, CHD8 . Tra...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 02e83f38-5ead-52c0-974e-c60d5cecfa43
- DOI
- 10.1101/2022.08.26.504147