Article
Into the Wild: A novel wild-derived inbred strain resource expands the genomic and phenotypic diversity of laboratory mouse models.
PLoS genetics - 1 Apr 2024
Dumont Beth L, Gatti Daniel M, Ballinger Mallory A, Lin Dana, Phifer-Rixey Megan, Sheehan Michael J, Suzuki Taichi A, Wooldridge Lydia K, Frempong Hilda Opoku, Lawal Raman Akinyanju, Churchill Gary A, Lutz Cathleen, Rosenthal Nadia, White Jacqueline K, Nachman Michael W
Abstract excerpt
The laboratory mouse has served as the premier animal model system for both basic and preclinical investigations for over a century. However, laboratory mice capture only a subset of the genetic variation found in wild mouse populations, ultimately limiting the potential of classical inbred strains to uncover phenotype-associated variants and pathways. Wild mouse populations are reservoirs of genetic diversity...
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