Article

Generation of <i>C9orf72</i> repeat knock-in iPSC lines for modelling ALS and FTD

2025-02-11

Abstract excerpt

Induced pluripotent stem cell (iPSC) models are powerful tools for neurodegenerative disease modelling, as they allow mechanistic studies in a human genetic environment and they can be differentiated into a range of neuronal and non-neuronal cells. However, these models come with inherent challenges due to line-to-line and clonal variability. To combat this issue, the iPSC Neurodegenerative Disease Initiative (iND...

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Literature Corpus work: f9b9580d-3a10-58a3-ab15-91a81fe22762
DOI: 10.1101/2025.02.10.637041

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