Article
Retrospective cell lineage reconstruction in humans by using short tandem repeats.
Cell reports methods - 26 Jul 2021
Tao Liming, Raz Ofir, Marx Zipora, Ghosh Manjusha S, Huber Sandra, Greindl-Junghans Julia, Biezuner Tamir, Amir Shiran, Milo Lilach, Adar Rivka, Levy Ron, Onn Amos, Chapal-Ilani Noa, Berman Veronika, Ben Arie Asaf, Rom Guy, Oron Barak, Halaban Ruth, Czyz Zbigniew T, Werner-Klein Melanie, Klein Christoph A, Shapiro Ehud
Abstract excerpt
Cell lineage analysis aims to uncover the developmental history of an organism back to its cell of origin. Recently, novel in vivo methods utilizing genome editing enabled important insights into the cell lineages of animals. In contrast, human cell lineage remains restricted to retrospective approaches, which still lack resolution and cost-efficient solutions. Here, we demonstrate a scalable platform based on...
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