Article

Aberrant sorting of hippocampal complex pyramidal cells in Type I Lissencephaly alters topological innervation

2020-02-07

Abstract excerpt

Layering has been a long-appreciated feature of higher order mammalian brain structures but the extent to which it plays an instructive role in synaptic specification remains unknown. Here we examine the formation of synaptic circuitry under cellular heterotopia in hippocampal CA1, using a mouse model of the human neurodevelopmental disorder Type I Lissencephaly. We identify calbindin-expressing principal cells wh...

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Literature Corpus work: 524ccd33-a0c6-558a-b817-150f9479cd46
DOI: 10.1101/2020.02.05.935775

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