Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.

Neuroscience - 10 Nov 2011

Edwards A, Treiber C D, Breuss M, Pidsley R, Huang G-J, Cleak J, Oliver P L, Flint J, Keays D A

Abstract excerpt

The Jenna mutant mouse harbours an S140G mutation in Tuba1a that impairs tubulin heterodimer formation resulting in defective neuronal migration during development. The consequence of decreased neuronal motility is a fractured pyramidal cell layer in the hippocampus and wave-like perturbations in the cerebral cortex. Here, we extend our characterisation of this mouse investigating the laminar architecture of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Mice, Mutant Strains

Share to Neurogenesis

Share to Reflex, Startle

Share to Superior Colliculi

Share to Tubulin

Source

Open in PubMed Open full text

Identifiers

PMID: 21875651
DOI: 10.1016/j.neuroscience.2011.08.035
PMCID: PMC3188702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytoarchitectural disruption of the superior colliculus and an enlarged acoustic startle response in the Tuba1a mutant mouse.PMID 21875651Read ↗

Neuropathological phenotype of a distinct form of lissencephaly associated with mutations in TUBA1A.Semantic proximity Read ↗

Emergence of Non-Canonical Parvalbumin-Containing Interneurons in Hippocampus of a Murine Model of Type I LissencephalySemantic proximity Read ↗

Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.Semantic proximity Read ↗

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.Semantic proximity Read ↗

A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.Semantic proximity Read ↗

Genetic mechanisms underlying abnormal neuronal migration in classical lissencephaly.Semantic proximity Read ↗

Differential requirements of tubulin genes in mammalian forebrain developmentSemantic proximity Read ↗

Developmental alterations of the septohippocampal cholinergic projection in a lissencephalic mouse model.Semantic proximity Read ↗

Microtubule binding protein Togaram1 is required for proper development of mammalian forebrain and neural primary ciliaSemantic proximity Read ↗

Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant.Semantic proximity Read ↗

Lipid transport is necessary for neocortical laminationSemantic proximity Read ↗

Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.