Article

A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity

2026-01-28

Abstract excerpt

<h4>Background</h4> Cytoskeletal structure and neuronal function are heavily intertwined, and altered pyramidal neuron morphology (e.g., reduced dendritic arbors) has been consistently identified in the neocortex of individuals with psychiatric disorders. A missense mutation in Kalrn ( Kalrn -PT) enhances activation of RhoA, a cytoskeletal regulator, and leads to adolescent-onset dendritic regression in supragr...

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Literature Corpus work: 9442b216-7d5e-5e29-a8a3-613a79b47ff3
DOI: 10.64898/2026.01.28.702244

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