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Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of <i>Dyrk1A</i>

2023-03-09

Abstract excerpt

<h4>SUMMARY</h4> Abnormal dendritic arbors, dendritic spine “dysgenesis” and excitation inhibition imbalance are main traits assumed to underlie impaired cognition and behavioral adaptation in intellectual disability. However, how these modifications actually contribute to functional properties of neuronal networks, such as signal integration or storage capacity is unknown. Here, we used a mouse model overexpress...

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Literature Corpus work
828a7302-626e-51fa-acd1-4435f2393549
DOI
10.1101/2023.03.09.531874
Open publication

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Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of <i>Dyrk1A</i>DOI 10.1101/2023.03.09.531874
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