Article

SEIZURE OCCURRENCE IN FCD TYPE II IS PREDICTED BY LESION POSITION AND LINKED TO CYTOARCHITECTURAL ALTERATIONS

2025-10-20

Abstract excerpt

<h4>ABSTRACT</h4> Focal cortical dysplasia (FCD) is a common malformation of cortical development and a major cause of early-onset, drug-resistant epilepsy. FCD type II is defined by abnormal lamination, altered cellular composition, and pathological cells, notably dysmorphic neurons (DNs) and balloon cells. DNs are thought to drive epileptogenicity through both cell-autonomous and non-cell-autonomous mechanisms,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5731ab8-3b7b-5c00-8f75-10ad0620b387
DOI: 10.1101/2025.10.20.683364

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SEIZURE OCCURRENCE IN FCD TYPE II IS PREDICTED BY LESION POSITION AND LINKED TO CYTOARCHITECTURAL ALTERATIONSDOI 10.1101/2025.10.20.683364Read

Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis.Semantic proximity Read

Focal Cortical Dysplasia: Gene Mutations, Cell Signaling, and Therapeutic Implications.Semantic proximity Read

Focal cortical dysplasia type II: review of neuropathological manifestations and pathogenetic mechanismsSemantic proximity Read

Somatic Mosaicism Patterns Define Clinical-Surgical Subtypes of Focal Cortical Dysplasia Through Cell-Type-Specific ExpressionSemantic proximity Read

Deep histopathology genotype-phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb.Semantic proximity Read

Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: insights into disease mechanisms and tissue characterizationSemantic proximity Read

New developments in understanding focal cortical malformations.Semantic proximity Read

[Advances of pathological research and classification in malformations of cortical development associated with refractory epilepsy].Semantic proximity Read

Focal cortical dysplasia: a practical guide for neurologists.Semantic proximity Read

Dissecting the genetic basis of focal cortical dysplasia: a large cohort studySemantic proximity Read

Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signaturesSemantic proximity Read

Spatial omics reveals molecular changes in focal cortical dysplasia type IISemantic proximity Read