Article
Synthetically Lethal Biomimetic Nutri-hijacker Hitchhikes and Reprograms KRAS Mutation-Driven Metabolic Addictions for Pancreatic Ductal Adenocarcinoma Treatment.
ACS nano - 25 Jul 2023
Huang Yukun, Chen Yu, Zhou Songlei, Xie Laozhi, Liang Kaifan, Xu Jianpei, Zhang Qian, Chen Huan, Wang Dayuan, Song Qingxiang, Jiang Gan, Mei Ni, Ma Fenfen, Lu Huiping, Gao Xiaoling, Chen Jun
Abstract excerpt
Metabolic therapy targeting the metabolic addictions driven by gain-of-function mutations in KRAS is promising in fighting cancer through selective killing of malignant cells without hurting healthy cells. However, metabolic compensation and heterogeneity make current metabolic therapies ineffective. Here, we proposed a biomimetic "Nutri-hijacker" with "Trojan horse" design to induce synthetic lethality in...
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