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Article

DNAJA1 Dysregulates Metabolism Promoting an Antiapoptotic Phenotype in Pancreatic Ductal Adenocarcinoma.

Journal of proteome research - 6 Aug 2021

Roth Heidi E, Bhinderwala Fatema, Franco Rodrigo, Zhou You, Powers Robert

Abstract excerpt

The cochaperone protein DNAJA1 (HSP40) is downregulated four-fold in pancreatic cancer cells. The impact of DNAJA1 expression on pancreatic ductal adenocarcinoma (PDAC) progression remains unclear. The metabolic impacts of increased DNAJA1 expression were evaluated using a combination of untargeted metabolomics, stable isotope-resolved metabolomics (SIRM), confocal microscopy, flow cytometry, and cell-based...

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Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

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Share to Gene Expression Regulation, Neoplastic

Share to HSP40 Heat-Shock Proteins

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Source

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Identifiers

PMID: 34264680
DOI: 10.1021/acs.jproteome.1c00233
PMCID: PMC8823314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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