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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

1 Apr 2018

Abstract excerpt

A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten −/− ; Trp53 −/− fibroblasts and their Pten -WT reference. Highly selective killing of Pten -null cells can be achieved by deguelin, a natural insecticide. Deguelin eliminates Pten -deficient cells through inhibition of mitochondrial complex I...

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PMID: 29617673
DOI: 10.1016/j.celrep.2018.03.032

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