Article

Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib

2023-07-01

Abstract excerpt

<h4>Summary</h4> Isocitrate dehydrogenase (IDH)-mutant gliomas have distinctive metabolic and biological traits that may render them susceptible to targeted treatments. Here, by conducting a high-throughput drug screen, we pinpointed a specific susceptibility of IDH-mutant gliomas to zotiraciclib (ZTR). ZTR exhibited selective growth inhibition across multiple IDH-mutant glioma in vitro and in vivo models. Mech...

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Literature Corpus work: d4d68996-06fe-5bc9-af5d-214ff701efda
DOI: 10.1101/2023.06.29.547143

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