Article

Cancer cells are sensitive to wild-type IDH1 inhibition under nutrient limitation

2020-11-20

Abstract excerpt

Pancreatic cancer cells alter their metabolism to survive cancer-associated stress (1-4). For example, cancer cells must adapt to steep nutrient gradients that characterize the natural tumor microenvironment (TME) (5-7). In the absence of adaptive strategies, harsh metabolic conditions promote the generation of free radicals (8) and impair energy production in tumor cells. Towards this end, wild-type isocitrate de...

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Literature Corpus work: 32197fa6-e4e0-5cc3-ab43-387f109ec107
DOI: 10.1101/2020.11.19.390633

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