Article

Targeting dormant ovarian cancer cells <i>in vitro</i> and in an <i>in vivo</i> model of platinum resistance

2019-07-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Ovarian cancer cells often exist in vivo as multicellular spheroids. Spheroid formation in vitro has been used to enrich for cancer stem cell populations from primary tumors. Such spheroids exhibit drug resistance and slow proliferation, suggesting involvement in disease recurrence. Our objectives were to characterize cancer spheroid phenotypes, determine gene expression pr...

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Literature Corpus work: 52372ea2-c795-5ddf-85ea-e974f4a934d0
DOI: 10.1101/716464

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