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Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

1 Oct 2010

Abstract excerpt

Aldehyde dehydrogenase-1A1 (ALDH1A1) expression characterizes a subpopulation of cells with tumor-initiating or cancer stem cell properties in several malignancies. Our goal was to characterize the phenotype of ALDH1A1-positive ovarian cancer cells and examine the biological effects of ALDH1A1 gene silencing. In our analysis of multiple ovarian cancer cell lines, we found that ALDH1A1 expression and activity was...

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PMID: 20889728
DOI: 10.1158/1535-7163.mct-10-0563

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