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Establishment and Characterization of an <i>In Vitro</i> Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity

15 Dec 2015

Abstract excerpt

The establishment of cancer stem-like cell (CSC) culture systems may be instrumental in devising strategies to fight refractory cancers. Inhibition of the Rho kinase ROCK has been shown to favorably affect CSC spheroid cultures. In this study, we show how ROCK inhibition in human serous ovarian cancer (SOC) cells can help establish a CSC system, which illuminates cancer pathophysiology and its treatment in this...

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PMID: 26669863
DOI: 10.1158/0008-5472.can-15-0361

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