Article

Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8⁺ T cells

2026-03-13

Abstract excerpt

<title>Abstract</title> <p> Most antitumor CD8 <sup>⁺</sup> T cells in patients exhibit dysfunctional phenotypes, limiting the efficacy of adoptive cell transfer (ACT) against cancer. Although cancer vaccines can induce antitumor stem-like T cell (T <sub>SL</sub> ) phenotypes, whether they can reverse T cell dysfunction during ACT remains unclear. Using murine neoantigen-specific tumor models, we show that c...

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Literature Corpus work: 52199c12-d60c-5abf-b97e-f53b69a64ce8
DOI: 10.21203/rs.3.rs-8941883/v1

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