Article

Systemic neoantigen-specific T cells reveal central determinants of PD-(L)1 blockade efficacy

2026-03-12

Abstract excerpt

The contribution of neoantigen-specific T cells to PD-(L)1 efficacy has largely been inferred from tumor mutational burden. We functionally profiled circulating T cell responses against 7,038 predicted HLA-I–restricted and 21,453 HLA-II–restricted neopeptides in 27 patients with advanced non-small cell lung cancer treated with anti–PD-(L)1. CD4 responses were frequent and correlated with neoantigen availability bu...

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Literature Corpus work: 273491d9-9c10-5072-b0df-cfac2ff681ec
DOI: 10.64898/2026.03.10.710196

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