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Emerging Strategies in TCR-Engineered T Cells

30 Mar 2022

Abstract excerpt

Immunotherapy of cancer has made tremendous progress in recent years, as demonstrated by the remarkable clinical responses obtained from adoptive cell transfer (ACT) of patient-derived tumor infiltrating lymphocytes, chimeric antigen receptor (CAR)-modified T cells (CAR-T) and T cell receptor (TCR)-engineered T cells (TCR-T). TCR-T uses specific TCRS optimized for tumor engagement and can recognize epitopes...

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PMID: 35432319
DOI: 10.3389/fimmu.2022.850358

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