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Long-term efficacy of adoptive cell therapy is determined by host CD8 <sup>+</sup> T cells and undermined by lymphodepleting preconditioning

2024-05-21

Abstract excerpt

Adoptive T cell therapy (ACT) has demonstrated remarkable efficacy in treating hematological cancers. However, its efficacy against solid tumors remains limited and the emergence of cancer cells that lose expression of targeted antigens often promotes resistance to ACT. Importantly, the mechanisms underlying effective and durable ACT-mediated tumor control are incompletely understood. Here, we show that adoptive t...

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Literature Corpus work
70a09215-ae50-59be-acea-b916c2aeb8da
DOI
10.1101/2024.05.16.594554
Open publication

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Long-term efficacy of adoptive cell therapy is determined by host CD8 <sup>+</sup> T cells and undermined by lymphodepleting preconditioningDOI 10.1101/2024.05.16.594554
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