Article

Cross-competition shapes CD8+ T cell hierarchies and fate after cancer neoantigen RNA vaccination

2026-03-24

Abstract excerpt

<title>Abstract</title> <p>Cancer patients typically mount T cell responses to only a small fraction of the neoantigens encoded in their individualized vaccine. Because each patient’s neoantigen set is unique, clinical studies cannot determine whether this restricted breadth reflects limitations of neoantigen prediction algorithms or intrinsic immunological constraints. Here, using a clinically relevant multi-neo...

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Literature Corpus work: 2a2acf5c-d39b-5702-8795-ca3cb9d1e859
DOI: 10.21203/rs.3.rs-8304459/v1

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