Article
Pathogenic inflammation in the CNS of mice carrying human PLP1 mutations.
Human molecular genetics - 1 Nov 2016
Groh Janos, Friedman Hana C, Orel Nadiya, Ip Chi Wang, Fischer Stefan, Spahn Irene, Schäffner Erik, Hörner Michaela, Stadler David, Buttmann Mathias, Varallyay Csanad, Solymosi László, Sendtner Michael, Peterson Alan C, Martini Rudolf
Abstract excerpt
Progressive forms of multiple sclerosis lead to chronic disability, substantial decline in quality of life and reduced longevity. It is often suggested that they occur independently of inflammation. Here we investigated the disease progression in mouse models carrying PLP1 point mutations previously found in patients displaying clinical features of multiple sclerosis. These mouse models show loss-of-function of...
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