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Article

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.

The Journal of clinical investigation - 1 Jun 2014

Cruz-Orengo Lillian, Daniels Brian P, Dorsey Denise, Basak Sarah Alison, Grajales-Reyes José G, McCandless Erin E, Piccio Laura, Schmidt Robert E, Cross Anne H, Crosby Seth D, Klein Robyn S

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory disease of the CNS that is characterized by BBB dysfunction and has a much higher incidence in females. Compared with other strains of mice, EAE in the SJL mouse strain models multiple features of MS, including an enhanced sensitivity of female mice to disease; however, the molecular mechanisms that underlie the sex- and strain-dependent differences in disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Encephalomyelitis, Autoimmune, Experimental

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Source

Open in PubMed Open full text

Identifiers

PMID: 24812668
DOI: 10.1172/JCI73408
PMCID: PMC4089451

Genes

CXCL12
CDC42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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