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Article

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise.

Virulence - 1 Dec 2026

Bohner Flora, Szilovics Zora, Veres Éva, Papp Csaba, Nosanchuk Joshua D, Gácser Attila

Abstract excerpt

Candida auris is an emerging multidrug-resistant pathogen with high transmissibility in healthcare settings. Although echinocandin resistance in Candida is typically associated with fitness loss, we found that micafungin-resistant C. auris strains (MICAevo) generated from two distinct source isolates (AR0381 and AR0387) via experimental microevolution retained full virulence. Evolved strains developed stable...

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Identifiers

PMID: 42051239
DOI: 10.1080/21505594.2026.2664993
PMCID: PMC13134414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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