Article

Defining the signalling determinants of a posterior ventral spinal cord identity in human neuromesodermal progenitor derivatives

2020-06-24

Abstract excerpt

The anteroposterior axial identity of motor neurons (MNs) determines their functionality and vulnerability to neurodegeneration. Thus it is a critical parameter in the design of strategies aiming to produce MNs from human pluripotent stem cells (hPSCs) for regenerative medicine and disease modelling applications. However, the in vitro generation of posterior spinal cord MNs has been challenging. Although the indu...

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Literature Corpus work: 51ee41d2-433b-5f09-b99f-38fb322c17f6
DOI: 10.1101/2020.06.24.168625

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