Article

Coordinated alternative splicing decisions via stepwise exon definition

2024-12-21

Abstract excerpt

Alternative splicing of pre-mRNA is a fundamental step in human gene regulation and aberrant slic-ing is tightly linked to diseases including cancer. Various splicing events, such as alternative exon (AE) choice and intron retention (IR), are controlled by a common molecular machinery, the spliceo-some. However, it remains elusive how the regulation of spliceosome activity coordinately affects these splicing decis...

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Literature Corpus work: 09cc82b6-eb4b-5b83-b733-32c0e6651a65
DOI: 10.1101/2024.12.18.629257

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