Succession of splicing regulatory elements determines cryptic 5΄ss functionality.

doi:10.1093/nar/gkw1317

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Succession of splicing regulatory elements determines cryptic 5΄ss functionality.

Nucleic acids research - 20 Apr 2017

Brillen Anna-Lena, Schöneweis Katrin, Walotka Lara, Hartmann Linda, Müller Lisa, Ptok Johannes, Kaisers Wolfgang, Poschmann Gereon, Stühler Kai, Buratti Emanuele, Theiss Stephan, Schaal Heiner

Abstract excerpt

A critical step in exon definition is the recognition of a proper splice donor (5΄ss) by the 5' end of U1 snRNA. In the selection of appropriate 5΄ss, cis-acting splicing regulatory elements (SREs) are indispensable. As a model for 5΄ss recognition, we investigated cryptic 5΄ss selection within the human fibrinogen Bβ-chain gene (FGB) exon 7, where we identified several exonic SREs that simultaneously acted on...

Topics

Exons
Fibrinogen
HeLa Cells
Humans
Mutation
RNA Splice Sites
RNA, Small Nuclear
Regulatory Sequences, Ribonucleic Acid
Serine-Arginine Splicing Factors

Source

Open in PubMed

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open full text

Identifiers

PMID: 28039323
DOI: 10.1093/nar/gkw1317
PMCID: PMC5397162

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.