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Article

Coordinated alternative splicing decisions via stepwise exon definition.

Nucleic acids research - 5 May 2026

Kristofori Panajot, Xiao Zijie, Braun Simon, Busch Anke, Zarnack Kathi, König Julian, Legewie Stefan, Li Congxin

Abstract excerpt

Alternative splicing of pre-mRNA is a fundamental step in human gene regulation, and aberrant splicing is frequently linked to complex diseases, including cancer. All splicing events, such as skipping or inclusion of an alternative exon (AE) and intron retention (IR), are regulated by a common molecular machinery, the spliceosome. However, it remains elusive how the spliceosome coordinates different splicing...

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PMID: 42152680
DOI: 10.1093/nar/gkag464
PMCID: PMC13183682

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