Article

Three components of human brain gene expression reflect normative developmental programmes with specific links to neurodevelopmental disorders

2022-10-06

Abstract excerpt

Human brain organisation emerges from the coordinated transcription of thousands of genes, and the first principal component (C1) of spatial whole genome expression was shown to reflect cortical hierarchy. Here, optimised processing of the Allen Human Brain Atlas revealed two new components of brain transcription, C2 and C3, which were distinctively enriched for neuronal, metabolic and immune processes, cell-types...

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Literature Corpus work: dcf84ebd-41b6-5f83-b407-52d824d75671
DOI: 10.1101/2022.10.05.510582

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