Article

An MRI-informed histo-molecular analysis implicates ependymal cells in the pathogenesis of periventricular pathology in multiple sclerosis

2025-01-15

Abstract excerpt

It is now widely recognized that the cerebrospinal fluid (CSF)-adjacent brain surfaces – namely the subpial cortical region and the ependyma-adjacent periventricular region – are uniquely susceptible to a distinct, diffuse form of pathology in multiple sclerosis. So-called surface-in gradients of pathology predict future disease relapses independent of classical white matter lesions and are thought to occur as a...

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Literature Corpus work: 51ad8590-1279-5a20-93f4-5d70ba67575e
DOI: 10.1101/2025.01.14.633055

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