Article

Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity

2025-09-25

Abstract excerpt

<title>Abstract</title> <p>Chronic neuroinflammation and neurodegeneration are critical but unresolved drivers of disability accumulation in progressive multiple sclerosis (MS). Chronic active white matter lesions, identifiable radiologically as paramagnetic rim lesions (PRL), indicate progression-relevant chronic neuroinflammation. Using single-cell transcriptomics (scRNAseq) and T-cell receptor sequencing (scTC...

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Literature Corpus work: 350a8860-1d5e-553e-b0b8-ef3ffaa1f5ee
DOI: 10.21203/rs.3.rs-7633686/v1

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