Article

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis pathophysiology

2025-07-06

Abstract excerpt

<h4>Background</h4> Multiple sclerosis is a neurodegenerative autoimmune disorder of the central nervous system (CNS) in which autoreactive immune cells migrate through a damaged blood brain barrier, resulting in focal demyelinating lesions of both the white and grey matter. Of increasing interest is the repeated observation that beyond focal lesions, there are also diffuse, surface-in gradients of pathology in M...

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Literature Corpus work: 2606bd99-180e-546f-89f4-c4c58dead830
DOI: 10.1101/2025.07.06.663378

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