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Article

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication.

Molecular neurodegeneration - 3 May 2025

Zhao Xiaojie, Li Yan, Zhang Siwei, Sudwarts Ari, Zhang Hanwen, Kozlova Alena, Moulton Matthew J, Goodman Lindsey D, Pang Zhiping P, Sanders Alan R, Bellen Hugo J, Thinakaran Gopal, Duan Jubao

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms have not been extensively studied. METHODS: Bulk ATAC-seq was performed in induced pluripotent stem cells (iPSCs) differentiated various brain cell types to identify allele-specific open chromatin (ASoC) SNPs. CRISPR-Cas9 editing...

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Alzheimer Disease
Astrocytes
Cell Communication
Clusterin
Induced Pluripotent Stem Cells

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PMID: 40319306
DOI: 10.1186/s13024-025-00840-1
PMCID: PMC12049787

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CLU

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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