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Article

Silent Myocardial Infarction Revisited: Immuno-metabolic Mechanisms, Multimodal Biomarkers, and Translational Diagnostics.

Journal of cardiovascular translational research - 5 Mar 2026

Pethani Yashvi, Pethani Neha, Pethani Dilip, Shah Rima, Shah Darshil, Shah Jignesh

Abstract excerpt

Silent Myocardial Infarction (SMI) is a clinically underrecognized phenotype along the myocardial infarction continuum that progresses without anginal symptoms. Its prevalence in diabetes, chronic kidney disease, and the elderly reflects contributions from neuropathy, autonomic dysfunction, and neurogenic silencing. Emerging evidence indicates that SMI reflects a biologically biased phenotype within the...

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PMID: 41784746
DOI: 10.1007/s12265-026-10755-x

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