Article

Empagliflozin targets a renal neuro-epithelial-immune axis in heart failure

2026-04-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Persistent neurohormonal activation is a key driver of maladaptive remodeling and disease progression in heart failure (HF). Sodium-glucose cotransporter 2 inhibitors (SGLT2is) confer robust renoprotective effects in HF; however, the extent to which these benefits involve modulation of renal neurohormonal activity remains unclear. We hypothesized that SGLT2i-mediated renopro...

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Literature Corpus work: 5b0d13fd-8b3b-552b-850a-298a3c505915
DOI: 10.64898/2026.03.31.715595

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