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Article

Empagliflozin attenuates inflammation levels in autoimmune myocarditis through the STAT3 pathway and macrophage phenotype transformation.

Molecular immunology - 1 Mar 2024

Sheng Wenxin, Yu Jianshu, Zhang Hao, Zhang Jingbo

Abstract excerpt

OBJECTIVE: To investigate the anti-inflammatory actions and molecular mechanisms of the sodium/glucose cotransporter 2 (SGLT-2) inhibitor empagliflozin on autoimmune myocarditis. METHODS: The experimental autoimmune myocarditis (EAM) mouse model was constructed using peptides, and the therapeutic effects of empagliflozin on cardiac inflammation and fibrosis were observed using hematoxylin and eosin (HE), Sirius...

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Identifiers

PMID: 38354482
DOI: 10.1016/j.molimm.2024.02.006

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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