Assessing the inference of single-cell phylogenies and population dynamics from CRISPR lineage recordings

Abstract excerpt

Multicellular organisms develop from a single cell by repeated rounds of cell division, differentiation, and death, which can be represented as a single-cell phylogenetic tree. Genetic lineage tracing allows us to investigate this development by tracking the ancestry of individual cells as populations grow and change over time. However, accurate reconstruction of the cell phylogeny and quantification of the corres...

Topics

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• Algorithms
• Cell Lineage
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Mutation
• Phylogeny
• Single-Cell Analysis
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

630695ba-85a3-535d-97e3-cfe38dd6ff62

DOI

10.1101/2025.01.08.631854