Article

Reconstructing signaling histories of single cells via perturbation screens and transfer learning

2025-03-17

Abstract excerpt

Manipulating the signaling environment is an effective approach to alter cellular states for broad-ranging applications, from engineering tissues to treating diseases. Such manipulation requires knowing the signaling states and histories of the cells in situ , for which high-throughput discovery methods are lacking. Here, we present an integrated experimental-computational framework that learns signaling response...

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Literature Corpus work: 92c5bef8-db42-59a4-8dc0-ea67b39d76f1
DOI: 10.1101/2025.03.16.643448

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