Article

Tet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling

2023-05-02

Abstract excerpt

Mutations in human TET proteins have been found in individuals with neurodevelopmental disorders. Here we report a new function of Tet in regulating Drosophila early brain development. We found that mutation in the Tet DNA-binding domain ( Tet AXXC ) resulted in axon guidance defects in the mushroom body (MB). Tet is required in early brain development during the outgrowth of MB β axons. Transcriptomic study sh...

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Literature Corpus work: 518fb7b1-4c92-5fca-8921-0f767c547b2c
DOI: 10.1101/2023.05.02.539069

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