Article

UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability

2025-07-30

Abstract excerpt

Johanson-Blizzard Syndrome (JBS) is an autosomal recessive spectrum disorder associated with the UBR-1 ubiquitin ligase that features developmental delay including motor abnormalities. Here, we demonstrate that C. elegans UBR-1 regulates high-intensity locomotor behavior and developmental viability via both ubiquitin ligase and scaffolding mechanisms. Super-resolution imaging with CRISPR-engineered UBR-1 and gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a280129-e8aa-5312-9f6b-7398ecd69c96
DOI: 10.1101/2025.07.28.666006

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viabilityDOI 10.1101/2025.07.28.666006Read

The UBR-1 Ubiquitin Ligase Regulates Glutamate Metabolism to Generate Coordinated Motor Pattern in <i>C. elegans</i>Semantic proximity Read

The ubiquitin ligase UBR-1 regulates the synaptic strength between the GABAergic and glutamatergic signalingSemantic proximity Read

Genetic modeling of GNAO1 disorder delineates mechanisms of Gαo dysfunction.Semantic proximity Read

Heterozygous UBR5 variants result in a neurodevelopmental syndrome with developmental delay, autism, and intellectual disability.Semantic proximity Read

Elucidating the Biochemical Role of Novel Enzyme Targets in Neurodegenerative DisordersSemantic proximity Read

The C. elegans glutamate transporters GLT-4 and GLT-5 regulate protein expression, behavior, and lifespan.Semantic proximity Read

Fused in sarcoma regulates glutamate signaling and oxidative stress response.Semantic proximity Read

Uncovering the essential roles of human GCP 2 orthologs in <i>Caenorhabditis elegans</i>Semantic proximity Read

A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate.Semantic proximity Read

Decoding GNAO1 Mutations Using <em>Caenorhabditis elegans</em> Model System: Past Approaches and Future ProspectivesSemantic proximity Read

The Effect of glna Loss on the Physiological and Pathological Phenotype of Parkinson's Disease C. elegans.Semantic proximity Read

Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.Semantic proximity Read