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Article

CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins.

eLife - 2 Jun 2016

Chen Lizhen, Liu Zhijie, Zhou Bing, Wei Chaoliang, Zhou Yu, Rosenfeld Michael G, Fu Xiang-Dong, Chisholm Andrew D, Jin Yishi

Abstract excerpt

Axon injury triggers dramatic changes in gene expression. While transcriptional regulation of injury-induced gene expression is widely studied, less is known about the roles of RNA binding proteins (RBPs) in post-transcriptional regulation during axon regeneration. In C. elegans the CELF (CUGBP and Etr-3 Like Factor) family RBP UNC-75 is required for axon regeneration. Using crosslinking immunoprecipitation...

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Identifiers

PMID: 27253061
DOI: 10.7554/eLife.16072
PMCID: PMC4946901

Genes

CELF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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