Article

Tuba1a is uniquely important for axon guidance through midline commissural structures

2020-05-06

Abstract excerpt

Developing neurons undergo dramatic morphological changes to appropriately migrate and extend axons to make synaptic connections. The microtubule cytoskeleton, made of α/β-tubulin dimers, drives neurite outgrowth, promotes neuronal growth cone responses, and facilitates intracellular transport of critical cargoes during neurodevelopment. TUBA1A constitutes the majority of α-tubulin in the developing brain and mut...

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Literature Corpus work: 643281a0-6a91-5524-9118-aec05b17661e
DOI: 10.1101/2020.05.05.079376

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