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Article

tubb5 knockout in zebrafish causes neurodevelopmental defects via notch pathways.

Human molecular genetics - 1 Jun 2026

Liu Huihui, Li Jinze, Xiao Linglu, Hou Meiqi, Zi Zhike, Zhang Xianqin

Abstract excerpt

Mutations in TUBB5 cause complex cortical dysplasia with other brain malformations. However, the pathogenic mechanisms underlying TUBB5 mutations remain incompletely understood. We generated tubb5 knockout zebrafish using CRISPR/Cas9 genome editing technology. Homozygous mutants were lethality within two weeks post-fertilization along with developmental delay, craniofacial malformations, uncoordinated movement...

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PMID: 42241496
DOI: 10.1093/hmg/ddag041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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